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Index > Protein center > Mmel1(Gene name) > Mouse
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  • Mmel1 (Gene name),
  • Membrane metallo-endopeptidase-like 1 (Protein name ),  MMEL1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Mmel1(Nep2;Nl1;Sep);
    Protein name:
    Membrane metallo-endopeptidase-like 1;
    Alternative:
    Neprilysin II(NEPII);NEP2(m);Neprilysin-like 1(NL-1);Neprilysin-2(NEP2;NL2);Soluble secreted endopeptidase;Neprilysin-like peptidase(NEPLP);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificiy with MME and cleaves peptides at the same amide bond.
    Subcellular Location:
    Membrane Single-pass type II membrane protein Secreted A secreted form produced by proteollytic cleavage also exists.
    Protein Attributes:
    Sequence length:
    765
    Sequence:
    50:
    MVERAGWCRK | KSPGFVEYGL | MVLLLLLLGA | IVTLGVFYSI | GKQLPLLTSL | 
    100:
    LHFSWDERTV | VKRALRDSSL | KSDICTTPSC | VIAAARILEN | MDQSRNPCEN | 
    150:
    FYQYACGGWL | RHHVIPETNS | RYSVFDILRD | ELEVILKGVL | EDSTSQHRPA | 
    200:
    VEKAKTLYRS | CMNQSVIEKR | DSEPLLSVLK | MVGGWPVAMD | KWNETMGLKW | 
    250:
    ELERQLAVLN | SQFNRRVLID | LFIWNDDQNS | SRHVIYIDQP | TLGMPSREYY | 
    300:
    FQEDNNHKVR | KAYLEFMTSV | ATMLRKDQNL | SKESAMVREE | MAEVLELETH | 
    350:
    LANATVPQEK | RHDVTALYHR | MDLMELQERF | GLKGFNWTLF | IQNVLSSVEV | 
    400:
    ELFPDEEVVV | YGIPYLENLE | DIIDSYSART | MQNYLVWRLV | LDRIGSLSQR | 
    450:
    FKEARVDYRK | ALYGTTVEEV | RWRECVSYVN | SNMESAVGSL | YIKRAFSKDS | 
    500:
    KSTVRELIEK | IRSVFVDNLD | ELNWMDEESK | KKAQEKAMNI | REQIGYPDYI | 
    550:
    LEDNNKHLDE | EYSSLTFYED | LYFENGLQNL | KNNAQRSLKK | LREKVDQNLW | 
    600:
    IIGAAVVNAF | YSPNRNQIVF | PAGILQPPFF | SKDQPQSLNF | GGIGMVIGHE | 
    650:
    ITHGFDDNGR | NFDKNGNMLD | WWSNFSARHF | QQQSQCMIYQ | YGNFSWELAD | 
    700:
    NQNVNGFSTL | GENIADNGGV | RQAYKAYLRW | LADGGKDQRL | PGLNLTYAQL | 
    750:
    FFINYAQVWC | GSYRPEFAVQ | SIKTDVHSPL | KYRVLGSLQN | LPGFSEAFHC | 
    765:
    PRGSPMHPMK | RCRIW
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    Pfam:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Membrane metallo-endopeptidase-like 1
    Cat.:
    E2033h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Membrane metallo-endopeptidase-like 1
    Cat.:
    E2033r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Membrane metallo-endopeptidase-like 1
    Cat.:
    E2033m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Membrane metallo-endopeptidase-like 1
    Cat.:
    U2033h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Membrane metallo-endopeptidase-like 1
    Cat.:
    U2033m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Membrane metallo-endopeptidase-like 1
    Cat.:
    U2033r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Membrane metallo-endopeptidase-like 1
    Cat.:
    P2033Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Membrane metallo-endopeptidase-like 1
    Cat.:
    P2033Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Membrane metallo-endopeptidase-like 1
    Cat.:
    P2033Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Membrane metallo-endopeptidase-like 1
    Monoclonal Antibody for Mouse Membrane metallo-endopeptidase-like 1
    Monoclonal Antibody for Mouse Membrane metallo-endopeptidase-like 1
    Protein for Mouse Membrane metallo-endopeptidase-like 1
    Protein for Mouse Membrane metallo-endopeptidase-like 1
    Protein for Mouse Membrane metallo-endopeptidase-like 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides."
      Ikeda K. , Emoto N. , Raharjo S.B. , Nurhantari Y. , Saiki K. , Yokoyama M. , Matsuo M.
      J. Biol. Chem.274:32469-32477(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;GLYCOSYLATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Testis.
    2. 2.
      "Molecular cloning and biochemical characterization of a new mouse testis soluble zinc-metallopeptidase of the neprilysin family."
      Ghaddar G. , Ruchon A.F. , Carpentier M. , Marcinkiewicz M. , Seidah N.G. , Crine P. , DesGroseillers L. , Boileau G.
      Biochem. J.347:419-429(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);GLYCOSYLATION;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF 62-LYS-ARG-63
      tissue: Testis.
    3. 3.
      "Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases."
      Shirotani K. , Tsubuki S. , Iwata N. , Takaki Y. , Harigaya W. , Maruyama K. , Kiryu-Seo S. , Kiyama H. , Iwata H. , Tomita T. , Iwatsubo T. , Saido T.C.
      J. Biol. Chem.276:21895-21901(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;ENZYME REGULATION
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-765
      strain: NOD.
    5. 5.
      "Reduced fertility in male mice deficient in the zinc metallopeptidase NL1."
      Carpentier M. , Guillemette C. , Bailey J.L. , Boileau G. , Jeannotte L. , DesGroseillers L. , Charron J.
      Mol. Cell. Biol.24:4428-4437(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
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